胡文獻(xiàn)，男，副主任醫(yī)師，浙江大學(xué)腫瘤學(xué)碩士生導(dǎo)師、醫(yī)學(xué)博士，浙江大學(xué)醫(yī)學(xué)院附屬邵逸夫醫(yī)院副主任醫(yī)師。曾在美國的癌癥研究中心安德森癌癥中心（M.D. Anderson Cancer Center）從事惡性腫瘤的臨床基礎(chǔ)研究近3年。對腫瘤外科疾病（乳腺腫瘤、甲狀腺腫瘤）的微創(chuàng)手術(shù)及綜合治療等有豐富的臨床經(jīng)驗。1998年-2002年 杭州市第二人民醫(yī)院普外科2002年-2009年 浙江大學(xué)醫(yī)學(xué)院腫瘤學(xué)碩士博士連讀2006年-2008年美國的癌癥中心----安德森癌癥中心（M.D. Anderson Cancer Center）從事醫(yī)學(xué)臨床基礎(chǔ)研究2009年-至今 浙江大學(xué)醫(yī)學(xué)院附屬邵逸夫醫(yī)院腫瘤外科 主攻方向：腫瘤外科 （乳腺腫瘤、胃腸腫瘤及甲狀腺軟組織腫瘤）醫(yī)生擅長：乳腺腫瘤、胃腸腫瘤及甲狀腺軟組織腫瘤的外科治療和綜合治療。尤其對乳腺癌化療耐藥機制、胃癌及結(jié)腸癌的新輔助化療預(yù)測及微創(chuàng)手術(shù)等有較深入地研究。醫(yī)療成果：已發(fā)表論文近20余篇，SCI收錄論文12篇。其中以作者和通訊作者身份發(fā)表的SCI論文6篇，較高影響因子為6.747分。作為主持人承擔(dān)了自然科學(xué)青年基金1項和錢江人才計劃項目1項，同時作為主要參與者承擔(dān)課題1項及浙江省自然科學(xué)基金核心項目1項等。主要論文：1. Kenzhen Lv,?Liqun Liu, Linbo Wang, Jiren Yu, Xiaojiao Liu, Yongxia Cheng, Minjun Dong, Rongyue Teng, Linjiao Wu, Peifen Fu, Wuguo Deng, *Wenxian Hu, Lisong Teng. Lin28 Mediates Paclitaxel Resistance by Modulating p21, Rb and Let-7a miRNA in Breast Cancer Cells, PLoS one, 7(7):e40008, 2012. （通訊作者）2. He Y, Zhou Z, Hofstetter WL, Zhou Y, Hu W, Guo C, Wang L, Guo W, Pataer A, Correa AM, Lu Y, Wang J, Diao L, Byers LA, Wistuba II, Roth JA, Swisher SG, Heymach JV, Fang B. Aberrant expression of proteins involved in signal transduction and DNA repair pathways in lung cancer and their association with clinical parameters. PLoS One, 7(2):e31087, 2012.3. Yanbin Zhou, Wayne L. Hofstetter, Yong He, Wenxian Hu, Abujiang Pataer, Li Wang, Ji Wang, Yihong Zhou, Liping Yu, Bingliang Fang, Stephen G. Swisher. KLF4 inhibition of lung cancer cell invasion by suppression of SPARC expression. Cancer biology & therapy, 9(7):1-7, 2010.4. Wenxian Hu, Wayne L, Hofstetter, Hong Li, Yanbin Zhou, Yong He, Abujiang Pataer, Li Wang, Keping Xie, Stephen G. Swisher and Bingliang Fang. Putative Tumor-Suppressive Function of Krüppel-Like Factor 4 in Primary Lung Carcinoma, Clinical Cancer Research, 15(18):5688-5695, 2009.5. Hu W, Hofstetter W, Wei X, Guo W, Zhou Y, Pataer A, Li H, Fang B, Swisher SG. Double-Stranded RNA-Dependent Protein Kinase (PKR)-Dependent Apoptosis Induction by a Novel Small Compound. Journal of Pharmacology and Experimental Therapeutics, 328(3):866-872, 2009.6. Hu W, Hofstetter W, Guo W, Li H, Pataer A, Peng HH, Guo ZS, Bartlett DL, Lin A, Swisher SG, Fang B. JNK-deficiency enhanced oncolytic vaccinia virus replication and blocked activation of double-stranded RNA-dependent protein Kinase. Cancer Gene Therapy, 15(9):616-624, 2008.7. Hu Wenxian, Bartlett David L, Swisher Stephen G, Fang Bingliang. Redirecting adaptive immunity against foreign antigens to tumors for cancer therapy. Cancer biology & therapy, 6(11):1773-1779, 2007.8. Pataer A, Hu W, Xiaolin L, Chada S, Roth JA, Hunt KK, Swisher SG. Adenoviral endoplasmic reticulum-targeted mda-7/interleukin-24 vector enhances human cancer cell killing. Molecular Cancer Therapeutics, 7(8):2528-2535, 2008.